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Anti-DC-SIGN antibody (ab5716)

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1 question for ab5716

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Question 1

Monday 28-February-2005

Hello, I would like to know if your DC-SIGN antibody will block DC-SIGN's binding pocket, in otherword, can the antibody bind DC-SIGN while it is simultaneously binding a sugar? Thank you

ANSWER:

  

Thank you for your enquiry.

This antibody was raised against residues 277 to 293 of human DC-SIGN. This region is part of the C-type Lectin Domain. Unfortunately, since this antibody is generated against a linear peptide from the protein, we do not know how the antibodies will bind to the protein in the native conformation and affect the binding sites.

We apologise for the inconvenience,

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