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Overview

  • Product nameDC-SIGN peptideSee all DC-SIGN proteins and peptides ...
  • Protein descriptionThis peptide was used as an immunogen for ab94714 - Anti-DC-SIGN antibody.

    • Properties

  • Purity70 - 90% by HPLC
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab94714.

    • Protein info

    • Alternative names
        C type lectin domain family 4 member LC-type lectin domain family 4 member LCD 209
        CD209CD209 antigenCD209 antigen-like protein ACD209 moleculeCD209_HUMANCd209aCDSIGNCIRECLEC4LDC SIGNDC SIGN1DC-SIGNDC-SIGN1DCSIGNDendritic cell specific ICAM 3 grabbing nonintegrin 1Dendritic cell specific ICAM3 grabbing nonintegrin 1Dendritic cell-specific ICAM-3-grabbing non-integrin 1Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrinDengue fever, protection against, includedDentritic Cell Specific ICAM3 Grabbing NonintegrinHIV GP120 Binding ProteinMGC129965MGC130443SIGN-R1SIGNR5
      see all
  • FunctionPathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens, including HIV-1 gp120, HIV-2 gp120, SIV gp120, ebolavirus glycoproteins, cytomegalovirus gB, HCV E2, dengue virus gE, Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA.
    On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.
  • Tissue specificityPredominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
  • Sequence similaritiesContains 1 C-type lectin domain.
  • DomainThe tandem repeat domain, also called neck domain, mediates oligomerization.
  • Cellular localizationSecreted and Cell membrane.

    • Target information above from: UniProt accession Q9NNX6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for DC-SIGN peptide (ab108464)

    ab108464 has not yet been referenced specifically in any publications.

    Publishing research using ab108464 ? Please let us know so that we can cite the reference in this datasheet

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