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Anti-DCC antibody [DM51] (ab49169)

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Overview

Product name

Anti-DCC antibody [DM51]
See all DCC products (7) ...

Description

Mouse monoclonal [DM51] to DCC

Tested applications

IHC-Pmore details

Cross reactivity

Reacts with

Human

Immunogen

Prokaryotic recombinant fusion protein corresponding to a 205 amino acid portion of the intracellular domain of the Human DCC molecule.

Positive control

Human bowel tissue.

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: Tissue culture supernatant

Purity

Tissue culture supernatant

Clonality

Monoclonal

Clone number

DM51

Myeloma

P3-NS1/1-Ag4-1

Isotype

IgG1

Light chain type

kappa

Research areas

Epigenetics and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Neuroscience >> Neurology process >> Neurogenesis
Neuroscience >> Neurology process >> Growth and Development >> Axonal Guidance Proteins
Cell Biology >> Apoptosis >> Receptors >> Associated Proteins

Applications

Show applications key

Our Abpromise guarantee covers the use of ab49169 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • IHC-P

     

Application notes

IHC-P: 1/20 - 1/40.
High temperature antigen unmasking technique. 60 minutes primary antibody incubation at 25°C recommended.

Is unsuitable for IHC-Fr or WB.

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Tissue specificity

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.

Involvement in disease

Defects in DCC are the cause of congenital mirror movements (MIMOC) [MIM:157600]. Mirror movements are contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.

Sequence similarities

Belongs to the immunoglobulin superfamily. DCC family.
Contains 6 fibronectin type-III domains.
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Post-translational
modifications

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.

Cellular localization

Membrane.

Target information above from: UniProt accessionP43146 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Colorectal cancer related chromosome sequence 18 antibody
  • Colorectal cancer suppressor antibody
  • CRC 18 antibody
  • CRC18 antibody
  • CRCR 1 antibody
  • CRCR1 antibody
  • DCC antibody
  • DCC_HUMAN antibody
  • Deleted in colorectal cancer protein antibody
  • Deleted in colorectal carcinoma antibody
  • Immunoglobulin superfamily DCC subclass member 1 antibody
  • Netrin receptor DCC antibody
  • Tumor suppressor protein DCC antibody
see all

Database links

References for Anti-DCC antibody [DM51] (ab49169)

ab49169 has not yet been referenced specifically in any publications.

Publishing research using ab49169? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"