Overview

Description

  • NatureSynthetic
  • Amino Acid Sequence
    • SpeciesHuman
    • SequenceC-DGEKANKDA EQKED
    • Amino acids352 to 365

Specifications

Our Abpromise guarantee covers the use of ab45880 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Store at -20°C. Stable for 12 months at -20°C

General info

  • Alternative names
    • DCDC 2
    • DCDC2
    • DCDC2_HUMAN
    • DCDC2A
    • Doublecortin domain containing 2
    • doublecortin domain containing protein 2
    • Doublecortin domain-containing protein 2
    • HGNC:18141
    • KIAA1154
    • Protein RU2S
    • RU 2
    • RU2
    • RU2S
    • RU2S protein
    see all
  • FunctionMay be involved in neuronal migration during development of the cerebral neocortex.
  • Tissue specificityUbiquitously expressed. In brain, highly expressed in the entorhinal cortex, inferior temporal cortex, medial temporal cortex, hypothalamus, amygdala and hippocampus.
  • Involvement in diseaseDefects in DCDC2 may be a cause of susceptibility to dyslexia type 2 (DYX2) [MIM:600202]; also known as specific reading disability type 2. Dyslexia is a relatively common, complex cognitive disorder that affects 5% to 10% of school-aged children. The disorder is characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities and in the absence of sensory or neurological disability.
  • Sequence similaritiesContains 2 doublecortin domains.
  • Target information above from: UniProt accession Q9UHG0 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

References for DCDC2 peptide (352-365) (ab45880)

ab45880 has not yet been referenced specifically in any publications.

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