DDB2 peptide (ab87818)
- damage-specific DNA binding protein 2Damage-specific DNA-binding protein 2DDB p48 subunit
- Ddb2DDB2_HUMANDDBbDNA damage-binding protein 2UV-damaged DNA-binding protein 2UV-DDB 2
Contains 5 WD repeats.
modificationsPhosphorylation by ABL1 negatively regulate UV-DDB activity.
Ubiquitinated by CUL4A in response to UV irradiation. Ubiquitination appears to both impair DNA-binding and promotes ubiquitin-dependent proteolysis. Degradation of DDB2 at sites of DNA damage may be a prerequisite for their recognition by XPC and subsequent repair. CUL4A-mediated degradation appears to be promoted by ABL1.
References for DDB2 peptide (ab87818)
ab87818 has not yet been referenced specifically in any publications.