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Western blot - DFNB31 antibody (ab57106)
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Product Name
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DFNB31 antibody
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See all DFNB31 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to DFNB31
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Immunogen
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Recombinant fragment: GLLEPTSTLV RVKKSAATLG IAIEGGANTR QPLPRIVTIQ RGGSAHNCGQ LKVGHVILEV NGLTLRGKEH REAARIIAEA FKTKDRDYID FLVTEFNVML , corresponding to amino acids 808-908 of Human DFNB31
BLAST 'GLLEPTSTLV RVKKSAATLG IAIEGGANTR QPLPRIVTIQ RGGSAHNCGQ LKVGHVILEV NGLTLRGKEH REAARIIAEA FKTKDRDYID FLVTEFNVML ' with  or 
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Reacts with
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Hu
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Tested applications
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 1-5 µg/ml.
This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic. Cell projection, stereocilium. Note: Detected at the level of stereocilia in inner hair cells and in outer hair cells in the cochlea. Colocalizes with the growing ends of actin filaments.
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Research areas
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Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Sensory System >> Visual system
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Relevance
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DFNB31 (deafness autosomal recessive 31) is a PDZ scaffold protein which is necessary for elongation and maintenance of stereocilia in the inner and outer hair cells in the organ of Corti in the inner ear. It is also expressed in retinal photoreceptor cells. Mutations in this gene, also known as Whirlin, are associated with non syndromic sensorineural deafness autosomal recessive type 31 and retinitis pigmentosa. DFNB31 interacts with a calmodulin dependent serine kinase, CASK, and may be involved in the formation of scaffolding protein complexes that facilitate synaptic transmission in the central nervous system.
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DFNB31 antibody (ab57106) |
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG2b
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Light chain type
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kappa
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Purity
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Protein G purified
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Storage buffer
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Preservative: None
PBS, pH 7.2
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this DFNB31 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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DFNB31 antibody images:
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 Western blot - DFNB31 antibody (ab57106)
Western blot against tagged recombinant protein immunogen using ab57106 DFNB31 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa
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Search PubMed (MEDLINE) for references to DFNB31
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DFNB31 antibody - more information
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Customer reviews (feedback) regarding DFNB31 antibody |
Customer FAQs regarding DFNB31 antibody |
Protocols for DFNB31 antibody |
Price and availability of products related to DFNB31 antibody |
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DFNB31 antibody - other tools:
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Contact Abcam with a Technical Enquiry about DFNB31 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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