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Product Name
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DFNB31 antibody
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See all DFNB31 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to DFNB31
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Immunogen
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Synthetic peptide derived from C terminal domain of human DFNB31 protein.
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Reacts with
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Hu
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Predicted to react
(species key)
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Ms, Rat
(Due to sequence homology)
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Specificity
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ab76848 reacts with all the isoforms of DFNB31.
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Tested applications
(see key)
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IHC-P, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/50 - 1/200.
WB: 1/100 - 1/1000. Predicted molecular weight: 96 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cytoplasmic. Cell projection, stereocilium. Note: Detected at the level of stereocilia in inner hair cells and in outer hair cells in the cochlea. Colocalizes with the growing ends of actin filaments.
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Research areas
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Neuroscience >> Sensory System >> Auditory system
Neuroscience >> Sensory System >> Visual system
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Relevance
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DFNB31 (deafness autosomal recessive 31) is a PDZ scaffold protein which is necessary for elongation and maintenance of stereocilia in the inner and outer hair cells in the organ of Corti in the inner ear. It is also expressed in retinal photoreceptor cells. Mutations in this gene, also known as Whirlin, are associated with non syndromic sensorineural deafness autosomal recessive type 31 and retinitis pigmentosa. DFNB31 interacts with a calmodulin dependent serine kinase, CASK, and may be involved in the formation of scaffolding protein complexes that facilitate synaptic transmission in the central nervous system.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Whole antiserum
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Storage buffer
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Preservative: None
Constituents: Whole serum
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Form
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Liquid
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Concentration
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Concentration not determined - why is this?
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this DFNB31 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to DFNB31
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DFNB31 antibody - more information
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Customer reviews (feedback) regarding DFNB31 antibody |
Customer FAQs regarding DFNB31 antibody |
Protocols for DFNB31 antibody |
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Contact Abcam with a Technical Enquiry about DFNB31 antibody |
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