You have changed your country from  to  . Please be aware that this will change the currency in the purchasing process.

Overview

  • Product nameAnti-DKK1 antibody [2H2]See all DKK1 primary antibodies ...
  • Description
    Mouse monoclonal [2H2] to DKK1
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified recombinant fragment of Human DKK1 expressed in E. coli.

  • Positive controlDKK1-hIgGFc transfected HEK293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab130191 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/2000. Predicted molecular weight: 29 kDa.

Target

  • FunctionAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificityPlacenta.
  • Sequence similaritiesBelongs to the dickkopf family.
  • DomainThe C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession O94907 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Dickkopf 1 antibodyDickkopf 1 homolog antibodyDickkopf 1 like antibody
        Dickkopf homolog 1 antibodyDickkopf like protein 1 antibodyDickkopf related protein 1 antibodyDickkopf-1 antibodyDickkopf-related protein 1 antibodyDKK 1 antibodyDkk-1 antibodyDkk1 antibodyDKK1_HUMAN antibodyhDkk 1 antibodyhDkk-1 antibodySK antibody
      see all

    Anti-DKK1 antibody [2H2] images

    • Western blot - Anti-DKK1 antibody [2H2] (ab130191)
      Western blot - Anti-DKK1 antibody [2H2] (ab130191)
      All lanes : Anti-DKK1 antibody [2H2] (ab130191) at 1/500 dilution

      Lane 1 : HEK293 cell lysate
      Lane 2 : DKK1-hIgGFc transfected HEK293 cell lysate


      Predicted band size : 29 kDa

    References for Anti-DKK1 antibody [2H2] (ab130191)

    ab130191 has not yet been referenced specifically in any publications.

    Publishing research using ab130191 ? Please let us know so that we can cite the reference in this datasheet

    Product Wall

    Submit an Abreview for ab130191 Submit a Question for ab130191

    There are currently no Abreviews or Questions for ab130191.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"