Overview

  • Product nameAnti-DKK1 antibody
    See all DKK1 primary antibodies
  • Description
    Mouse monoclonal to DKK1
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: QPYPCAEDEE CGTDEYCASP TRGGDAGVQI CLACRKRRKR CMRHAMCCPG NYCKNGICVS SDQNHFRGEI EETITESFGN DHSTLDGYSR RTTLSSKMYH , corresponding to amino acids 81-181 of Human DKK1

Properties

Applications

Our Abpromise guarantee covers the use of ab56905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
    • Tissue specificityPlacenta.
    • Sequence similaritiesBelongs to the dickkopf family.
    • DomainThe C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Dickkopf 1 antibody
      • Dickkopf 1 homolog antibody
      • Dickkopf 1 like antibody
      • Dickkopf homolog 1 antibody
      • Dickkopf like protein 1 antibody
      • Dickkopf related protein 1 antibody
      • Dickkopf-1 antibody
      • Dickkopf-related protein 1 antibody
      • DKK 1 antibody
      • Dkk-1 antibody
      • Dkk1 antibody
      • DKK1_HUMAN antibody
      • hDkk 1 antibody
      • hDkk-1 antibody
      • SK antibody
      see all

    Anti-DKK1 antibody images



    • Predicted band size : 29 kDa
      DKK1 antibody (ab56905) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    References for Anti-DKK1 antibody (ab56905)

    ab56905 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab56905.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"