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Overview

  • Product nameDKK1 peptideSee all DKK1 proteins and peptides ...
  • Protein length13 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab93017.

    • Protein info

    • Alternative names
        Dickkopf 1Dickkopf 1 homologDickkopf 1 like
        Dickkopf homolog 1Dickkopf like protein 1Dickkopf related protein 1Dickkopf-1Dickkopf-related protein 1DKK 1Dkk-1Dkk1DKK1_HUMANhDkk 1hDkk-1SK
      see all
  • FunctionAntagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • Tissue specificityPlacenta.
  • Sequence similaritiesBelongs to the dickkopf family.
  • DomainThe C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • Cellular localizationSecreted.

    • Target information above from: UniProt accession O94907 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for DKK1 peptide (ab101729)

    ab101729 has not yet been referenced specifically in any publications.

    Publishing research using ab101729 ? Please let us know so that we can cite the reference in this datasheet

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