Anti-DLL4 antibody (ab103469)

Overview

• Product nameAnti-DLL4 antibodySee all DLL4 primary antibodies ...
• Description
  Rabbit polyclonal to DLL4
• Tested applicationsWB, IHC-P more details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 631-661 of Human DLL4.

• Positive controlK562 cell line lysates. Brain tissue.

Properties

• FormLiquid
• Storage instructionsStore at 4°C (up to 6 months). For long term storage store at -20°C
• Storage bufferPreservative: 0.09% Sodium Azide
  Constituents: PBS
• Concentration information loading...
• PurityImmunogen affinity purified
• Purification notesThis antibody is purified through a protein A column, followed by peptide affinity purification.
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Epigenetics and Nuclear Signaling
  • Cell cycle
  • Cell Differentiation

  • Neuroscience
  • Neurology process
  • Notch Pathway

  • Cell Biology
  • Cell Cycle
  • Cell differentiation

Applications

Target

• FunctionPlays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4.
• Tissue specificityExpressed in vascular endothelium.
• Sequence similaritiesContains 1 DSL domain.
  Contains 8 EGF-like domains.
• DomainThe Delta-Serrate-Lag2 (DSL) domain is required for binding to the Notch receptor.
• Post-translational
  modificationsUbiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation.
• Cellular localizationMembrane.

Target information above from: UniProt accession Q9NR61 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 54567 Human
  • Entrez Gene: 54567 Human
  • Omim: 605185 Human
  • SwissProt: Q9NR61 Human
  • SwissProt: Q9NR61 Human
  • Unigene: 511076 Human

• Alternative names
  Delta 4 antibodydelta 4 precursor antibodyDelta ligand 4 antibody

  delta ligand 4 precursor antibodyDelta like 4 antibodyDelta like 4 homolog antibodyDelta like 4 protein antibodyDelta like protein 4 antibodyDelta-like 4 (Drosophila) antibodyDelta-like protein 4 antibodyDelta4 antibodyDLL 4 antibodyDll4 antibodyDLL4_HUMAN antibodyDrosophila Delta homolog 4 antibodyhdelta2 antibodyHomeobox protein DLL-4 antibodyMGC126344 antibodyNotch ligand delta 2 antibodyNotch ligand DLL4 antibodyNotch ligand DLL4 precursor antibodyXDLL-4 antibody

  see all

Anti-DLL4 antibody images

• 

  Western blot - DLL4 antibody (ab103469)
  Anti-DLL4 antibody (ab103469) at 1/100 dilution + K562 cell line lysates at 35 µg
  developed using the ECL technique
  
  Predicted band size : 75 kDa
  
• 

  Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - DLL4 antibody (ab103469)
  ab103469 at 1/50 dilution staining DLL4 in formalin-fixed and paraffin-embedded brain tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Detection utilised DAB.