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Anti-DOPA Decarboxylase antibody [DDC-109] (ab49916)

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Overview

Product name

Anti-DOPA Decarboxylase antibody [DDC-109]
See all DOPA Decarboxylase products (8) ...

Description

Mouse monoclonal [DDC-109] to DOPA Decarboxylase

Specificity

This antibody is specific to DOPA Decarboxylase

Tested applications

ICC/IF, WB, IP, Indirect ELISAmore details

Cross reactivity

Reacts with

Rat, Sheep, Rabbit, Guinea pig, Cow, Dog, Human, Monkey

Predicted to work with

Mouse, Pig, Zebrafish

Immunogen

A synthetic human DOPA Decarboxylase N terminal peptide (IEGRQVYPDVEPGYLR) corresponding to amino acids 24-39 conjugated to KLH.

IEGRQVYPDV EPGYLR

Run BLAST with BLAST the sequence with ExPASyRun BLAST with BLAST the sequence with NCBI

Positive control

WB: Bovine brain extract ICC/IF: Brain tissue

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 15mM Sodium Azide
Constituents: Ascites

Concentration

Concentration information loading...

Purity

Ascites

Primary antibody notes

In immunocytochemical labeling of brain tissue, the product stains the monoaminergic cells and proximal dendrites, but not cortical fibers.

Clonality

Monoclonal

Clone number

DDC-109

Isotype

IgG2b

Research areas

Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine

Applications

Show applications key

Our Abpromise guarantee covers the use of ab49916 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Function

Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Pathway

Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.

Involvement in disease

Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.

Sequence similarities

Belongs to the group II decarboxylase family.

Target information above from: UniProt accessionP20711 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • AADC antibody
  • Aromatic L Amino Acid Decarboxylase antibody
  • Aromatic-L-amino-acid decarboxylase antibody
  • Ddc antibody
  • DDC antibody
  • DDC protein antibody
  • DDC_HUMAN antibody
  • DOPA decarboxylase antibody
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Database links

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References for Anti-DOPA Decarboxylase antibody [DDC-109] (ab49916)

ab49916 has not yet been referenced specifically in any publications.

Publishing research using ab49916? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"