Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-DOPA Decarboxylase antibody
See all DOPA Decarboxylase products (9) ...
Description
Sheep polyclonal to DOPA Decarboxylase
Specificity
Ab27955 recognises DOPA Decarboxylase.
Tested applications
WB, Dot Blotmore details
Cross reactivity
Reacts with
Rat, Sheep, Rabbit, Guinea pig, Cow, Dog, Human
Immunogen
Recombinant full length protein: SDS denatured recombinant bovine DOPA Decarboxylase expressed in E. coli and purified from inclusion bodies.
Positive control
Adrenal medulla and caudate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, 0.1mg/ml BSA, 150mM Sodium chloride, 10mM HEPES. pH 7.5.
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Endocrine metabolism >> Hormone biosynthesis
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine
Applications
Show applications key
Our Abpromise guarantee covers the use of ab27955 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000. Predicted molecular weight: 54 kDa.
Dot Blot
Dot: 1/1000.Dot: 1/1000.
Target
Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Pathway
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
Involvement in disease
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
Sequence similarities
Belongs to the group II decarboxylase family.
Target information above from: UniProt accessionP20711
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
see all
Database links
- Entrez Gene: 280762 Cow
- Entrez Gene: 1644 Human
- Entrez Gene: 24311 Rat
- Omim: 107930 Human
- SwissProt: P27718 Cow
- SwissProt: P20711 Human
- SwissProt: P14173 Rat
- Unigene: 359698 Human
see all
References for Anti-DOPA Decarboxylase antibody (ab27955)
ab27955 has not yet been referenced specifically in any publications.
Publishing research using ab27955? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"