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Products:Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine
Overview
Product name
Anti-DOPA Decarboxylase antibody
See all DOPA Decarboxylase products (8) ...
Description
Rabbit polyclonal to DOPA Decarboxylase
Tested applications
Cross reactivity
Reacts with
Rat, Sheep, Rabbit, Guinea pig, Cow, Dog, Human
Immunogen
Synthetic peptide corresponding to amino acids from the N terminus of DOPA Decarboxylase (Human) conjugated to KLH.
Positive control
Bovine adrenal medulla lysate.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, 100µg/ml BSA, 150mM Sodium chloride, 10mM HEPES. pH 7.5
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine
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Western blot - DOPA Decarboxylase antibody (ab32587)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab32587 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: 1/1000Detects a band of approximately 55 kDa (predicted molecular weight: 54 kDa).
Target
Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Pathway
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
Involvement in disease
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
Sequence similarities
Belongs to the group II decarboxylase family.
Target information above from: UniProt accessionP20711
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
see all
Database links
- Entrez Gene: 280762 Cow
- Entrez Gene: 1644 Human
- Entrez Gene: 24311 Rat
- Omim: 107930 Human
- SwissProt: P27718 Cow
- SwissProt: P20711 Human
- SwissProt: P14173 Rat
- Unigene: 359698 Human
see all
Anti-DOPA Decarboxylase antibody images:
Western blot - DOPA Decarboxylase antibody (ab32587)
Anti-DOPA Decarboxylase antibody (ab32587) at 1/1000 dilution + bovine adrenal medulla lysate at 5 µg
Predicted band size : 54 kDa
Observed band size : 55 kDa (why is the actual band size different from the predicted?)
References for Anti-DOPA Decarboxylase antibody (ab32587)
ab32587 has not yet been referenced specifically in any publications.
Publishing research using ab32587? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"