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- Secondary antibodies
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Product name
Anti-DOPA Decarboxylase antibody
See all DOPA Decarboxylase products (9) ...
Description
Rabbit polyclonal to DOPA Decarboxylase
Tested applications
Cross reactivity
Reacts with
Rat
Immunogen
N-terminal synthetic peptide (Human) conjugated to KLH.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 10% Glycerol, 0.05% Tween 20, PBS, 1mg/ml BSA, 20mM Tris HCl, 10mM HEPES, 0.1% NaN3, 0.1% PVP-40. pH 7.2
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Metabolism >> Types of disease >> Cancer
Metabolism >> Pathways and Processes >> Endocrine metabolism >> Hormone biosynthesis
Cancer >> Cancer Metabolism >> Metabolic signaling pathway >> Hormone biosynthesis
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine
Applications
Show applications key
Our Abpromise guarantee covers the use of ab3906 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: Use at a concentration of 0.1 - 0.5 µg/ml.
By Western blot, this antibody detects a band of 55 kDa, which corresponds to the predicted molecular weight of DOPA Decarboxylase.
Much lower concentrations, than that suggested for Western blot, should be used in immunocytochemical applications.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Pathway
Catecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
Involvement in disease
Defects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
Sequence similarities
Belongs to the group II decarboxylase family.
Target information above from: UniProt accessionP20711
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- AADC antibody
- Aromatic L Amino Acid Decarboxylase antibody
- Aromatic-L-amino-acid decarboxylase antibody
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Database links
References for Anti-DOPA Decarboxylase antibody (ab3906)
ab3906 has not yet been referenced specifically in any publications.
Publishing research using ab3906? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"