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DOPA Decarboxylase protein (His tag) (ab85332)

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Overview

  • Product nameDOPA Decarboxylase protein (His tag)See all DOPA Decarboxylase proteins and peptides ...
  • Protein descriptionRecombinant full length Human DOPA Decarboxylase (aa 1-480) with N terminal His tag, 56kDa (Swiss-Prot P20711).
  • Expression hostE. coli

    • Properties

  • Purity> 95 % by SDS-PAGE
  • Purification notesab85332 is purified using conventional chromatography.
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    Constituents: 10% Glycerol, 20mM Tris HCl, 2mM DTT, pH 8.0
  • Concentration information loading...
  • Sequence notesMGSSHHHHHH SSGLVPRGSH TRSMNASEFR RRGKEMVDYV ANYMEGIEGR QVYPDVEPGY LRPLIPAAAP QEPDTFEDII NDVEKIIMPG VTHWHSPYFF AYFPTASSYP AMLADMLCGA IGCIGFSWAA SPACTELETV MMDWLGKMLE LPKAFLNEKA GEGGGVIQGS ASEATLVALL AARTKVIHRL QAASPELTQA AIMEKLVAYS SDQAHSSVER AGLIGGVKLK AIPSDGNFAM RASALQEALE RDKAAGLIPF FMVATLGTTT CCSFDNLLEV GPICNKEDIW LHVDAAYAGS AFICPEFRHL LNGVEFADSF NFNPHKWLLV NFDCSAMWVK KRTDLTGAFR LDPTYLKHSH QDSGLITDYR HWQIPLGRRF RSLKMWFVFR MYGVKGLQAY IRKHVQLSHE FESLVRQDPR FEICVEVILG LVCFRLKGSN KVNEALLQRI NSAKKIHLVP CHLRDKFVLR FAICSRTVES AHVQRAWEHI KELAADVLRA ERE
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab85332 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    SDS-PAGE SDS-PAGE: Use at an assay dependent dilution.
  • Application notesThis peptide can be used with studies using ab36155,ab49916 and ab113357.

    • Protein info

    • Alternative names
        AADCAromatic L Amino Acid DecarboxylaseAromatic-L-amino-acid decarboxylase
        DDCDdcDDC_HUMANDOPA decarboxylaseDOPA decarboxylase (aromatic L-amino acid decarboxylase)
      see all
  • FunctionCatalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
  • PathwayCatecholamine biosynthesis; dopamine biosynthesis; dopamine from L-tyrosine: step 2/2.
  • Involvement in diseaseDefects in DDC are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD) [MIM:608643]. AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. It causes developmental and psychomotor delay, poor feeding, lethargy, ptosis, intermittent hypothermia, gastrointestinal disturbances. The onset is early in infancy and inheritance is autosomal recessive.
  • Sequence similaritiesBelongs to the group II decarboxylase family.

    • Target information above from: UniProt accession P20711 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    DOPA Decarboxylase protein (His tag) images

    • SDS-PAGE - DOPA Decarboxylase protein (His tag) (ab85332)
      SDS-PAGE - DOPA Decarboxylase protein (His tag) (ab85332)
      15% SDS-PAGE analysis of 3µg ab85332

    References for DOPA Decarboxylase protein (His tag) (ab85332)

    ab85332 has not yet been referenced specifically in any publications.

    Publishing research using ab85332 ? Please let us know so that we can cite the reference in this datasheet

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