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Products:Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
Overview
Product name
Anti-DPP10 antibody - Stalk region
See all DPP10 products (7) ...
Description
Rabbit polyclonal to DPP10 - Stalk region
Specificity
This antibody recognises all four forms of DPP10. This antibody does not recognise other DPP family members
Tested applications
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Synthetic peptide corresponding to the stalk region of human DPP10.
(Peptide available as ab44601.)
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol, PBS, 0.5M Sodium chloride
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes >> Serine protease >> DPPs
Cell Biology >> Proteolysis / Ubiquitin >> Proteolytic enzymes
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Western blot - DPP10 antibody - Stalk region (ab42082)
(enlarge)
Applications
Show applications key
Our Abpromise guarantee covers the use of ab42082 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
- 1 Image
WB
Application notes
WB: 1/1000 - 1/5000. Predicted molecular weight: 91 kDa. Recommended starting dilution 1/1000 for use with colourimetric substrates, 1/5000 for use with chemiluminescent substrates. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Has no dipeptidyl aminopeptidase activity. May modulate cell surface expression and activity of the potassium channels KCND1 and KCND2.
Tissue specificity
Found in serum, T-cells and brain (at protein level). Expressed in brain, pancreas, spinal cord and adrenal glands.
Involvement in disease
Genetic variations in DPP10 are associated with susceptibility to asthma (ASTHMA) [MIM:600807]. The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with weezing due to spasmodic contraction of the bronchi.
Sequence similarities
Belongs to the peptidase S9B family. DPPIV subfamily.
Post-translational
modifications
N-glycosylated.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ8N608
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Dipeptidyl peptidase like protein 2 antibody
- DPPY antibody
- Dipeptidyl peptidase 10 antibody
see all
Database links
- Entrez Gene: 57628 Human
- Entrez Gene: 269109 Mouse
- Entrez Gene: 363972 Rat
- Omim: 608209 Human
- SwissProt: Q8N608 Human
- SwissProt: Q6NXK7 Mouse
- SwissProt: Q6Q629 Rat
- Unigene: 176247 Human
see all
Anti-DPP10 antibody - Stalk region images:
Western blot - DPP10 antibody - Stalk region (ab42082)
All lanes : Anti-DPP10 antibody - Stalk region (ab42082) at 1/1000 dilution
Lane 1 : Cell Line DU 145 SF treated
Lane 2 : Cell Line DU 145 RA treated
Predicted band size : 91 kDa
Observed band size : 96 kDa (why is the actual band size different from the predicted?)
Protocols
References for Anti-DPP10 antibody - Stalk region (ab42082)
ab42082 has not yet been referenced specifically in any publications.
Publishing research using ab42082? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"