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Western blot - DPP6 antibody (ab41809)
(enlarge)
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Product Name
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DPP6 antibody - Stalk region
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See all DPP6 antibodies (3)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to DPP6 - Stalk region
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Immunogen
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Synthetic peptide based on the stalk region of human DPP6.
(Peptide available as ab44766.)
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Reacts with
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Hu
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Predicted to react
(species key)
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Ms, Rat
(Due to sequence homology)
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Specificity
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This antibody will recognise all four forms of DPP6, but not the other family members.
We have a range of domain specific antibodies for this target. For a full list please see all DPP6 antibodies
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: 1/1000 when using colorimetric substrates such as BCIP/NBT, and 1/5000 for chemiluminescent substrates. Predicted molecular weight: 98 kDa. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Cell Membrane; single-pass type II membrane protein
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Research areas
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Signal Transduction >> Cytoskeleton / ECM >> Extracellular Matrix >> ECM Enzymes >> Other Enzymes
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Relevance
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DPP6 (DPPX, also known as potassium channel accelerating factor Dppx) is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.05% Sodium Azide
Constituents: 50% Glycerol Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this DPP6 antibody - Stalk region is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for DPP6 antibody - Stalk region images, references, products related to ab41809 and other tools.
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DPP6 antibody - Stalk region images:
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 Western blot - DPP6 antibody (ab41809)
All lanes : DPP6 antibody - Stalk region (ab41809) at 1/1000 dilution
Lane 1 : ESB
Lane 2 : Mouse Brain
Lane 3 : DU145 / IL1-beta Lysate
Lane 4 : DU145 / IL1-beta CM
Predicted band size : 98 kDa
Observed band size : 98 kDa
Additional bands at : 47 kDa (possible truncated form).
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Search PubMed (MEDLINE) for references to DPP6
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DPP6 antibody - Stalk region - more information
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Customer reviews (feedback) regarding DPP6 antibody - Stalk region |
Customer FAQs regarding DPP6 antibody - Stalk region |
Protocols for DPP6 antibody - Stalk region |
Price and availability of products related to DPP6 antibody - Stalk region |
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DPP6 antibody - Stalk region - related products:
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DPP6 antibody - Stalk region - other tools:
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Contact Abcam with a Technical Enquiry about DPP6 antibody - Stalk region |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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