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Overview

  • Product nameDPYD peptideSee all DPYD proteins and peptides ...
  • Protein descriptionSynthetic peptide of Human DPYD.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab95834 - DPYD antibody.
  • Molecular weight111kDa
  • Protein length17 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab95834.

    • Protein info

    • Alternative names
        DHPDHPDHaseDihydropyrimidine dehydrogenase
        Dihydropyrimidine dehydrogenase [NADP+]Dihydrothymine dehydrogenaseDihydrouracil dehydrogenaseDPDDPYDDPYD_HUMANMGC132008MGC70799OTTHUMP00000058954
      see all
  • FunctionInvolved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.
  • Tissue specificityFound in most tissues with greatest activity found in liver and peripheral blood mononuclear cells.
  • PathwayAmino-acid biosynthesis; beta-alanine biosynthesis.
  • Involvement in diseaseDefects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency (DPYD deficiency) [MIM:274270]; also known as hereditary thymine-uraciluria or familial pyrimidinemia. DPYD deficiency is a disease characterized by persistent urinary excretion of excessive amounts of uracil, thymine and 5-hydroxymethyluracil. Patients suffering from this disease show a severe reaction to the anticancer drug 5-fluorouracil. This reaction includes stomatitis, Leukopenia, thrombocytopenia, hair loss, diarrhea, fever, marked weight loss, cerebellar ataxia, and neurologic symptoms, progressing to semicoma.
  • Sequence similaritiesBelongs to the dihydropyrimidine dehydrogenase family.
    Contains 3 4Fe-4S ferredoxin-type domains.
  • Cellular localizationCytoplasm.

    • Target information above from: UniProt accession Q12882 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for DPYD peptide (ab105628)

    ab105628 has not yet been referenced specifically in any publications.

    Publishing research using ab105628 ? Please let us know so that we can cite the reference in this datasheet

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