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DR1 protein (T7 Tag) (ab40501)

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Overview

Product name

DR1 protein (T7 Tag)
See all DR1 products (4) ...

Protein description

Recombinant full length protein (Human). This protein has a T7 tag at the N-terminus.

Expression host

E. coli

Properties

Purity

> 95% by SDS-PAGE

Form

Liquid

Storage instructions

Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: 0.002% Sodium Azide
Constituents: 10mM Tris, 0.1% Triton X-100, pH 8.0

Concentration

Concentration information loading...

Research areas

Epigenetics and Nuclear Signaling >> Transcription >> Transcription Factors
Epigenetics and Nuclear Signaling >> Transcription >> Other factors
Epigenetics and Nuclear Signaling >> Transcription >> Polymerase associated factors >> Pol II Transcription >> Other

  • SDS-PAGE - DR1 protein (ab40501)SDS-PAGE - DR1 protein (ab40501) image (enlarge)

Applications

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Our Abpromise guarantee covers the use of ab40501 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

This peptide can be used with studies using ab28185.

Protein info

Function

The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Sequence similarities

Belongs to the NC2 beta/DR1 family.
Contains 1 histone-fold domain.

Post-translational
modifications

Phosphorylation regulates its interaction with TBP. Not phosphorylated when bound to DRAP1.

Cellular localization

Nucleus.

Target information above from: UniProt accessionQ01658 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

DR1 protein (T7 Tag) images:

  SDS-PAGE - DR1 protein (ab40501)

SDS-PAGE - DR1 protein (ab40501)

Analysis of DR1 Recombinant Protein (1µg). 4-20% SDS gradient gel. Coomassie blue staining. A band is seen at 19 kDa.

References for DR1 protein (T7 Tag) (ab40501)

ab40501 has not yet been referenced specifically in any publications.

Publishing research using ab40501? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"