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Overview

  • Product nameAnti-DR4 antibodySee all DR4 primary antibodies ...
  • Description
    Rabbit polyclonal to DR4
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide from N terminal residues of Human DR4 (NM_003844).

  • Positive controlK562, HeLa and RAW264.7 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab101012 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: 1/500 - 1/1000. Predicted molecular weight: 50 kDa.

Target

  • FunctionReceptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
  • Tissue specificityWidely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
  • Sequence similaritiesContains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • Cellular localizationMembrane.

    • Target information above from: UniProt accession O00220 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    • Alternative names
        Apo2 antibodyCD261 antibodyCytotoxic TRAIL receptor antibody
        Death receptor 4 antibodyDR4 antibodyNF related apoptosis-inducing ligand receptor 1 antibodyTNF-related apoptosis-inducing ligand receptor 1 antibodyTNFRSF10A antibodyTR10A_HUMAN antibodyTRAIL receptor 1 antibodyTRAIL-R1 antibodyTRAILR1 antibodyTumor necrosis factor receptor superfamily member 10A antibody
      see all

    Anti-DR4 antibody images

    • Western blot - DR4 antibody (ab101012)
      Western blot - DR4 antibody (ab101012)
      All lanes : Anti-DR4 antibody (ab101012) at 1/500 dilution

      Lane 1 : K562 Cell Lysate
      Lane 2 : HeLa Cell Lysate
      Lane 3 : RAW264.7 Cell Lysate


      Predicted band size : 50 kDa

    References for Anti-DR4 antibody (ab101012)

    ab101012 has not yet been referenced specifically in any publications.

    Publishing research using ab101012 ? Please let us know so that we can cite the reference in this datasheet

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    Dear xxxxxxx

    Thank you for looking into the query on TRAIL-R1 antibody for IHC on mouse tissue in paraffin.

    Regards

    Thank you for contacting us.


    I have looked into your requirement to have an antibody able to detect TRAIL-R1 for IHC of paraffin embedded mouse tissue.


    Unfortunately as discussed over the phone, we only have one antibody di...

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