Loading...
You have changed your country from
to
. Please be aware that this will change the currency in the purchasing process.
Related products
- Proteins and Peptides
- Secondary antibodies
Reassurance, Refunds & Replacements
If your product does not perform as described on this datasheet, we will refund or replace your product...
Read our guarantee »Overview
Product name
Anti-DR4 antibody
See all DR4 products (12) ...
Description
Rabbit polyclonal to DR4
Tested applications
Cross reactivity
Reacts with
Human
Immunogen
Synthetic peptide: ASGTEAAAATPSKVWGSSAG, corresponding to N terminal amino acids 24 - 43 of Human DR4, conjugated to KLH.
ASGTEAAAATPSKVWGSSAG
Positive control
Human cell lysates.
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide.
Constituents: PBS, pH 7.2.
Concentration
Concentration information loading...
Purity
IgG fraction
Purification notes
This antibody was purified by ion exchange.
Clonality
Polyclonal
Isotype
IgG
Research areas
Immunology >> Innate Immunity >> Cytokines >> TNF Superfamily
Cell Biology >> Apoptosis >> Receptors >> Death Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab28115 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Application notes
WB: Use at a concentration of 0.5 µg/ml for ECL. Detects a band of approximately 57 kDa (predicted molecular weight: 52 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Tissue specificity
Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.
Cellular localization
Membrane.
Target information above from: UniProt accessionO00220
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- Apo 2 antibody
- Apo2 antibody
- CD 261 antibody
see all
Database links
- Entrez Gene: 8797 Human
- Omim: 603611 Human
- SwissProt: O00220 Human
- Unigene: 213467 Human
- Unigene: 591834 Human
References for Anti-DR4 antibody (ab28115)
ab28115 has not yet been referenced specifically in any publications.
Publishing research using ab28115? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"