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- Primary antibodies
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Product name
DR4 peptide (450/468)
See all DR4 products (4) ...
Protein description
Synthetic peptide: CDSGKFIYLEDGTGSAVSLE, corresponding to amino acids 450/468 of Human DR4. This peptide was used as an immunogen for ab8414 - DR4 antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Concentration
Concentration information loading...
Sequence notes
CDSGKFIYLEDGTGSAVSLE Amino acids 427 to 445 of human DR4 (1)
Sequence
CDSGKFIYLEDGTGSAVSLE
Research areas
Immunology >> Innate Immunity >> Cytokines >> TNF Superfamily
Cell Biology >> Apoptosis >> Receptors >> Death Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab8446 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking
WB
Application notes
BL: Use at an assay dependent concentration.
WB: Use at an assay dependent concentration.
This peptide can be used with studies using ab8414.For blocking, incubate equal volumes of antibody and peptide, for for 30 min at 37°C.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Protein info
Function
Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Tissue specificity
Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.
Cellular localization
Membrane.
Target information above from: UniProt accessionO00220
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
References for DR4 peptide (450/468) (ab8446)
ab8446 has not yet been referenced specifically in any publications.
Publishing research using ab8446? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"