DRB (Benzimidazole), Casein kinase II inhibitor (ab120939)
Key features and details
- Casein kinase II inhibitor
- CAS Number: 53-85-0
- Purity: > 98%
- Soluble in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
DRB (Benzimidazole), Casein kinase II inhibitor -
Description
Casein kinase II inhibitor -
Alternative names
- Benzimidazole
- DiCl-RB
- NSC 401575
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Biological description
Casein kinase II inhibitor (Ki values are 23 and 48 μM for CKII and CKI, respectively). Inhibitor of RNA polymerase II transcription in vitro and in vivo. Shown to inhibit cyclin C/CDK8 (IC50 = 17 μM) and cyclin H/CDK7/p38 (IC50 = 18 μM) signaling. -
Purity
> 98% -
CAS Number
53-85-0 -
Chemical structure
Properties
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Chemical name
5,6-Dichloro-1-β-D-ribofuranosyl-1H-benzimidazole -
Molecular weight
319.14 -
Molecular formula
C12H12Cl2N2O4 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 25 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2cc(Cl)c(Cl)cc12 -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab120939 has been referenced in 3 publications.
- Lu JY et al. Genomic Repeats Categorize Genes with Distinct Functions for Orchestrated Regulation. Cell Rep 30:3296-3311.e5 (2020). PubMed: 32160538
- Bi X et al. RNA Targets Ribogenesis Factor WDR43 to Chromatin for Transcription and Pluripotency Control. Mol Cell 75:102-116.e9 (2019). PubMed: 31128943
- Faust TB et al. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:N/A (2018). PubMed: 29845934