Overview
- Product nameAnti-DYNC1I2 antibodySee all DYNC1I2 primary antibodies ...
- DescriptionRabbit polyclonal to DYNC1I2
- Tested applicationsWB more details
- Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow, Zebrafish - Immunogen
Recombinant protein fragment, corresponding to a region within amino acids 129 and 376 of Human DYNC1I2
- Positive controlHeLa whole cell lysate
Properties
- FormLiquid
- Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0 -
Concentration information loading... - PurityImmunogen affinity purified
- Clonality Polyclonal
- IsotypeIgG
- Research Areas
Applications
Our Abpromise guarantee covers the use of ab96288 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Notes |
|---|---|
| WB | WB: 1/500 - 1/3000. Predicted molecular weight: 71 kDa. |
Target
- FunctionActs as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
- Sequence similaritiesBelongs to the dynein intermediate chain family.
Contains 7 WD repeats. - Post-translational
modificationsPhosphorylated upon DNA damage, probably by ATM or ATR. The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding. - Cellular localizationCytoplasm > cytoskeleton.
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Database links
- Entrez Gene: 526329 Cow
- Entrez Gene: 1781 Human
- Entrez Gene: 1781 Human
- Entrez Gene: 13427 Mouse
- Entrez Gene: 116659 Rat
- Omim: 603331 Human
- SwissProt: Q0III3 Cow
- SwissProt: Q13409 Human
- SwissProt: Q13409 Human
- SwissProt: O88487 Mouse
- SwissProt: Q62871 Rat
- Unigene: 546250 Human
- Unigene: 249479 Mouse
- Unigene: 11014 Rat
see all
Target information above from: UniProt accession
Q13409
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010)
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Alternative names
- Cytoplasmic dynein 1 intermediate chain 2 antibodyCytoplasmic dynein intermediate chain 2 antibodycytosolic antibody
- DC1I2_HUMAN antibodyDH IC 2 antibodyDH IC-2 antibodyDNCI2 antibodyDNCIC2 antibodyDync1i2 antibodyDynein intermediate chain 2 antibodyDynein intermediate chain 2, cytosolic antibodyDynein, cytoplasmic, intermediate polypeptide 2 antibodyIC2 antibody
see all
Anti-DYNC1I2 antibody images
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Western blot - DYNC1I2 antibody (ab96288)Anti-DYNC1I2 antibody (ab96288) at 1/1000 dilution + HeLa whole cell lysate at 30 µg
Predicted band size : 71 kDa
References for Anti-DYNC1I2 antibody (ab96288)
ab96288 has not yet been referenced specifically in any publications.
