DYRK1A antibody (ab16140)

Product Name 

DYRK1A antibody

Product type 

Primary antibodies

Description 

Sheep polyclonal to DYRK1A

Immunogen 

Recombinant fragment, corresponding to amino acids 486-763 of Human DYRK1A.

Reacts with 
(species key)

Hu

Tested applications 
(see key)

ICC/IF, IP, WB

Abreviews 

Customer reviews (see key)

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Application notes 
(see key)

Recommended dilutions
IF: Use at a concentration of 1 - 10 µg/ml.
IP: Use at a concentration of 2 µg/ml.
WB: Use at a concentration of 1 µg/ml. Predicted molecular weight: 85 kDa.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Nuclear

Research areas 

Neuroscience >> Neurology process >> Neurogenesis

Relevance 

DYRK1A, the vertebrate of Drosophilia Minibrain, is a dual-specificity kinase predominately expressed in the central nervous system. The human clone has been isolated from the Downs' syndrome critical region and it is potentially implicated in the neuropathology of the disease. Main features of the protein include an N-terminal nuclear translocation signal, a putative leucine zipper domain, a core kinase domain with some similarity to kinases involved in cell cycle regulation and a C-terminal PEST sequence. The DYRK1A kinase can be phosphorylated on tyrosine residues, leading to an active kinase that can phosphorylated itself or exogenous substrates on both tyrosine and serine/threonine residues. DYRK1A can also multimerize and translocate to the nucleus. Present studies on DYRK1A suggest a potential role for this kinase in the exit from the cell cycle and the beginning of neuronal differentiation.

Database links 

Raised in 

Sheep

Clonality 

Polyclonal

Isotype 

IgG

Purity 

IgG fraction

Storage buffer 

Preservative: 0.08% Sodium Azide
Constituents: PBS

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

This antibody is provided as a 0.2 µm sterile filtered solution.

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

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