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Anti-DYRK1A antibody (ab65220)

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1 question for ab65220

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Question 1

Monday 01-December-2008

Can you tell me if these products, ab16140, ab65220, ab69811, ab71464 will only detect 「Dyrk1A」? It seems that similar products from other companies will also detect 「DYRK1B」 and 「 DYRK2」.

ANSWER:

  

Thank you for your enquiry.

ab16140：The antigen made to generate the antibody is specific to Dyrk1A. That said,　we have never actually tested against any other Dyrk protein, but the Dyrk1A　sequence differs so greatly from Dyrk1B that it would be highly unlikely for the antibody to cross react.

ab65220：The antibody only can detect DYRK1A according to the BLAST result.

ab71464：There is no information on cross reactivity with 「DYRK1B」or「 DYRK2」.

ab69811: Cross reactivity with DYRK1B and DYRK2 has not been tested.　However using the immunising sequence suggested in the datasheet (733-752 a.a) in a BLAST search, it appears there is little homology between the immunising sequence and DYRK1B and DYRK2.

I hope this information will be helpful.

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