Overview

  • Product nameAnti-DYX1C1 antibodySee all DYX1C1 primary antibodies ...
  • Description
    Rabbit polyclonal to DYX1C1
  • Tested applicationsELISA, WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Chimpanzee, Zebrafish
  • Immunogen

    A synthetic peptide corresponding to a region of human DYX1C1

  • Positive control
    • HeLa cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab75185 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.

ELISA titre using peptide based assay: 1/312500.

WB Use a concentration of 1 µg/ml. Detects a band of approximately 48 kDa (predicted molecular weight: 48 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

Target

  • FunctionInvolved in neuronal migration during development of the cerebral neocortex. May regulate the stability and proteasomal degradation of the estrogen receptors that play an important role in neuronal differentiation, survival and plasticity.
  • Tissue specificityExpressed in several tissues, including brain, lung, kidney and testis. In brain localizes to a fraction of cortical neurons and white matter glial cells.
  • Involvement in diseaseDefects in DYX1C1 may be a cause of susceptibility to dyslexia type 1 (DYX1) [MIM:127700]. A relatively common, complex cognitive disorder characterized by an impairment of reading performance despite adequate motivational, educational and intellectual opportunities. It is a multifactorial trait, with evidence for familial clustering and heritability. Note=A chromosomal aberration involving DYX1C1 has been found in a family affected by dyslexia. Translocation t(2;15)(q11;q21).
  • Sequence similaritiesContains 1 CS domain.
    Contains 3 TPR repeats.
  • Cellular localizationNucleus. Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • Dyslexia susceptibility 1 candidate 1 antibody
    • Dyslexia susceptibility 1 candidate gene 1 protein antibody
    • DYX1 antibody
    • DYX1C1 antibody
    • DYXC1 antibody
    • DYXC1_HUMAN antibody
    • EKN1 antibody
    • FLJ37882 antibody
    • MGC70618 antibody
    • RD antibody
    see all

Anti-DYX1C1 antibody images

  • Anti-DYX1C1 antibody (ab75185) at 1 µg/ml (in 5% skim milk / PBS buffer) + HeLa cell lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 48 kDa
    Observed band size : 48 kDa
    Additional bands at : 20 kDa. We are unsure as to the identity of these extra bands.

References for Anti-DYX1C1 antibody (ab75185)

ab75185 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab75185.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"