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Anti-Dact1 / Dapper homolog 1 antibody (ab72078)

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Overview

Product name

Anti-Dact1 / Dapper homolog 1 antibody
See all Dact1 / Dapper homolog 1 products (5) ...

Description

Rabbit polyclonal to Dact1 / Dapper homolog 1

Tested applications

WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Predicted to work with

Chicken, Xenopus laevis, Chimpanzee, Zebrafish

Immunogen

A portion of amino acids 725-775 of human Dact1 / Dapper homolog 1, (NP_057735).

Positive control

Human, mouse and rat brain lysate.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Storage buffer

Preservative: 0.05% Sodium Azide
Constituents: 0.05% BSA, PBS

Concentration

Concentration information loading...

Purity

Protein G purified

Clonality

Polyclonal

Isotype

IgG

  • Western blot - Dact1 / Dapper homolog 1 antibody (ab72078)Western blot - Dact1 / Dapper homolog 1 antibody (ab72078) image (enlarge)

Applications

Show applications key

Our Abpromise guarantee covers the use of ab72078 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application notes

WB: Use at a concentration of 0.5 - 1 µg/ml. Detects bands of approximately 24 and 110 kDa (predicted molecular weight: 90 kDa).

Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Target

Function

Positively regulates DVL2-mediated signaling pathways during development. Binds to DVL2 and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway.

Sequence similarities

Belongs to the dapper family.

Domain

The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins.

Cellular localization

Cytoplasm. Nucleus.

Target information above from: UniProt accessionQ9NYF0 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • Dact antibody
  • Dact1 antibody
  • DACT1_HUMAN antibody
  • Dapper antibody
  • Dapper homolog 1 antibody
  • Dpr antibody
  • Dpr1 antibody
  • Frd antibody
  • Frodo antibody
  • hDPR1 antibody
  • Hepatocellular carcinoma novel gene 3 protein antibody
  • HNG3 antibody
  • MTNG3 antibody
  • Thyex3 antibody
see all

Anti-Dact1 / Dapper homolog 1 antibody images:

  Western blot - Dact1 / Dapper homolog 1 antibody (ab72078)

Western blot - Dact1 / Dapper homolog 1 antibody (ab72078)

Lanes 1 - 2 : Anti-Dact1 / Dapper homolog 1 antibody (ab72078) at 1 µg/ml
Lanes 3 - 4 : Anti-Dact1 / Dapper homolog 1 antibody (ab72078) at 0.5 µg/ml

Lane 1 : Pre-immune sera
Lane 2 : Human brain lysate
Lane 3 : Mouse brain lysate
Lane 4 : Rat brain lysate


Predicted band size : 90 kDa
Observed band size : 110 kDa (why is the actual band size different from the predicted?)
Additional bands at : 24 kDa. We are unsure as to the identity of these extra bands.

References for Anti-Dact1 / Dapper homolog 1 antibody (ab72078)

ab72078 has not yet been referenced specifically in any publications.

Publishing research using ab72078? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"