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Overview

Properties

  • FormLiquid
  • Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: 0.1% Sodium Azide
    Constituents: 1% BSA, PBS
  • Concentration information loading...
  • PurityIon Exchange Chromatography
  • Clonality Monoclonal
  • Clone numberB-D44
  • Myelomax63-Ag8.653
  • IsotypeIgG1
  • Research Areas

Applications

Our Abpromise guarantee covers the use of ab46849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
Flow Cyt
  • Application notesFlow Cyt: Use 10µl for 106 cells or 100 µl of whole blood.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.

    • Target

    • RelevanceDcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
    • Cellular localizationCell Membrane and Cytoplasmic
    • Database links
      • Alternative names
          Antagonist decoy receptor for TRAIL/Apo 2L antibodyCD263 antibodyCytotoxic TRAIL receptor 3 antibody
          DCR1 antibodyDCR1 TNFR antibodyDecoy Receptor 1 antibodyDecoy TRAIL receptor without death domain antibodyLIT antibodyLymphocyte inhibitor of TRAIL antibodyMGC149501 antibodyMGC149502 antibodyTNF related apoptosis inducing ligand receptor 3 antibodyTNF-re ated apoptosis inducing ligand receptor 3 antibodyTNFRSF10C antibodyTRAIL R3 antibodyTRAIL receptor 3 antibodyTRAILR3 antibodyTRID antibodyTumor necrosis factor receptor superfamily member 10C antibodyTumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain antibody
        see all

      References for Anti-DcR1 antibody [B-D44] (ab46849)

      This product has been referenced in:
      • Mérino D  et al. Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol 26:7046-55 (2006). Read more (PubMed: 16980609) »

      See 1 Publication for this product

      Publishing research using ab46849 ? Please let us know so that we can cite the reference in this datasheet

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      Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"