Overview

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab6096 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Additional NotesStable for one year.


    Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL. Two decoy receptors for TRAIL have been identified and designated DcR1/TRID/TRAIL-R3/LIT and DcR2/TRAIL-R4/TRUNDD. DcR1 has extracellular TRAIL-binding domain but lacks intracellular signaling domain. It is a glycophospholipid-anchored cell surface protein. DcR1 transcripts are expressed in many normal human tissues but not in most cancer cell lines. Overexpression of DcR1 did not induce apoptosis, but attenuated TRAIL-induced apoptosis.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

General info

  • Alternative names
    • Antagonist decoy receptor for TRAIL/Apo 2L
    • CD263
    • Cytotoxic TRAIL receptor 3
    • DcR 1
    • DCR1
    • DCR1 TNFR
    • Decoy Receptor 1
    • Decoy TRAIL receptor without death domain
    • LIT
    • Lymphocyte inhibitor of TRAIL
    • MGC149501
    • MGC149502
    • TNF Related Apoptosis Inducing Ligand Receptor 3
    • TNF-re ated apoptosis inducing ligand receptor 3
    • TNFRSF10C
    • TRAIL R3
    • TRAIL receptor 3
    • TRAIL Receptor Without An Intracellular Domain
    • TRAILR3
    • TRID
    • Tumor Necrosis Factor Receptor Superfamily Member 10C
    • Tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
    see all
  • RelevanceDcR1 / TRAIL-R3 / TRID / LIT is one of the two putative decoy receptors identified for TRAIL, one of the members of TNF family of apoptosis inducing proteins. The other putative decoy receptor is called DcR2 / TRUNDD / TRAIL-R4. DcR1 is attached to the cell surface through glycophospholipid anchor. It has the extracellular TRAIL binding domain but lacks the cytoplasmic domain to induce apoptotic signal. Hence overexpression of DcR1 inhibits the TRAIL induced apoptosis.
  • Cellular localizationCell Membrane and Cytoplasmic

References for DcR1 peptide (ab6096)

ab6096 has not yet been referenced specifically in any publications.

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