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Products:Cell Biology >> Apoptosis >> Receptors >> Decoy Receptors
Overview
Product name
Anti-DcR2 antibody [B-P30]
See all DcR2 products (4) ...
Description
Mouse monoclonal [B-P30] to DcR2
Specificity
Recognises the TRAIL R4, a 44.2 kDa protein
Tested applications
WB, IPmore details
Cross reactivity
Reacts with
Human
Immunogen
Recombinant human DcR2/Fc chimera
Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Carrier and preservative free
Constituents: PBS
Concentration
Concentration information loading...
Purity
Ion Exchange Chromatography
Purification notes
Sterile-filtered through 0.22 µm
Clonality
Monoclonal
Clone number
B-P30
Myeloma
x63-Ag8.653
Isotype
IgG1
Research areas
Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> TRAIL
Immunology >> Innate Immunity >> Cytokines >> Necrosis Factors
Cell Biology >> Apoptosis >> Receptors >> Decoy Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab59511 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB: Use at an assay dependent dilution. Predicted molecular weight: 43 kDa.
IP: Use 10µl for 106 cells. (or 100 µl of whole blood.)
Target
Function
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Tissue specificity
Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ9UBN6
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD 264 antibody
- CD264 antibody
- CD264 antigen antibody
see all
Database links
- Entrez Gene: 8793 Human
- Omim: 603614 Human
- SwissProt: Q9UBN6 Human
- Unigene: 213467 Human
References for Anti-DcR2 antibody [B-P30] (ab59511)
ab59511 has not yet been referenced specifically in any publications.
Publishing research using ab59511? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"