Overview

  • Product nameAnti-DcR2 antibodySee all DcR2 primary antibodies ...
  • Description
    Rabbit polyclonal to DcR2
  • SpecificityHuman, Mouse, Rat
  • Tested applicationsICC, WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Peptide corresponding to amino acids 249 to 263 of human DcR2 precursor.

  • EpitopeGGPERVHRVLFRRRS
  • Positive control
    • HeLa whole cell lysate
  • General notesDecoy Receptor 2 for TRAIL

Properties

Applications

Our Abpromise guarantee covers the use of ab2019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC Use a concentration of 10 µg/ml.
WB 1/1000 - 1/2000. Can be blocked with DcR2 peptide (ab8379).
IHC-P Use at an assay dependent dilution.

Target

  • FunctionReceptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
  • Tissue specificityWidely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
  • Sequence similaritiesContains 1 death domain.
    Contains 3 TNFR-Cys repeats.
  • Cellular localizationMembrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • CD 264 antibody
    • CD264 antibody
    • DcR 2 antibody
    • DcR2 antibody
    • Decoy receptor 2 antibody
    • decoy with truncated death domain antibody
    • ID antibody
    • OTTHUMP00000123528 antibody
    • TNF receptor related receptor for TRAIL antibody
    • TNF related apoptosis inducing ligand receptor 4 antibody
    • TNF-related apoptosis-inducing ligand receptor 4 antibody
    • TNFRSF 10D antibody
    • TNFRSF10D antibody
    • TR10D_HUMAN antibody
    • TRAIL R4 antibody
    • TRAIL receptor 4 antibody
    • TRAIL receptor with a truncated death domain antibody
    • TRAIL-R4 antibody
    • TRAILR4 antibody
    • TRIALR 4 antibody
    • TRUNDD antibody
    • Tumor necrosis factor receptor superfamily member 10D antibody
    • Tumor necrosis factor receptor superfamily member 10d decoy with truncated death domain antibody
    • Tumor necrosis factor receptor superfamily member 10D precursor antibody
    • Tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain antibody
    see all

Anti-DcR2 antibody images

  • Anti-DcR2 antibody (ab2019) at 1/1000 dilution + HeLa whole cell lysate

    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
  • ab2019 at 10µg/ml staining DcR2 in human Hela cells by Immunocytochemistry.

References for Anti-DcR2 antibody (ab2019)

This product has been referenced in:
  • Laine A  et al. Senescence sensitivity of breast cancer cells is defined by positive feedback loop between CIP2A and E2F1. Cancer Discov 3:182-97 (2013). Human . Read more (PubMed: 23306062) »
  • Yu M  et al. Inactivation of TGF-ß signaling and loss of PTEN cooperate to induce colon cancer in vivo. Oncogene N/A:N/A (2013). Mouse . Read more (PubMed: 23604118) »

See all 4 Publications for this product

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Unfortunately I could not find in our system any order related to DcR1 and this Austrian research group. I would suggest your customer to contact directly the authors of this publication. Sorry I cannot be more helpful on this occasion.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"