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Products:Cell Biology >> Apoptosis >> Receptors >> Decoy Receptors
Overview
Product name
Anti-DcR2 antibody
See all DcR2 products (4) ...
Description
Rabbit polyclonal to DcR2
Specificity
Human, Mouse, Rat
Tested applications
ICC, WB, IHC-Pmore details
Cross reactivity
Reacts with
Mouse, Rat, Human
Immunogen
Peptide corresponding to amino acids 249 to 263 of human DcR2 precursor.
Epitope
GGPERVHRVLFRRRS
Positive control
HeLa whole cell lysate
General notes
Decoy Receptor 2 for TRAIL
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Preservative: 0.02% Sodium Azide
Constituents: PBS
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> TRAIL
Immunology >> Innate Immunity >> Cytokines >> Necrosis Factors
Cell Biology >> Apoptosis >> Receptors >> Decoy Receptors
Applications
Show applications key
Our Abpromise guarantee covers the use of ab2019 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ICC: Use a concentration of 10 µg/ml
WB: 1/1000 - 1/2000.
IHC-P: Use at an assay dependent dilution.
Target
Function
Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.
Tissue specificity
Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.
Sequence similarities
Contains 1 death domain.
Contains 3 TNFR-Cys repeats.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ9UBN6
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- CD 264 antibody
- CD264 antibody
- DcR 2 antibody
see all
Database links
- Entrez Gene: 8793 Human
- Omim: 603614 Human
- SwissProt: Q9UBN6 Human
- Unigene: 213467 Human
Anti-DcR2 antibody images:
Western blot - DcR2 antibody (ab2019)
Anti-DcR2 antibody (ab2019) at 1/1000 dilution + HeLa whole cell lysate
Observed band size : 35 kDa (why is the actual band size different from the predicted?)
Immunocytochemistry - DcR2 antibody (ab2019)
ab2019 at 10µg/ml staining DcR2 in human Hela cells by Immunocytochemistry.
References for Anti-DcR2 antibody (ab2019)
This product has been referenced in:
- Fan LCet al. a-Catulin knockdown induces senescence in cancer cells. Oncogene 30:2610-21 (2011). WB.Read more (PubMed: 21278790) »
- Fan Set al. Scatter factor protects tumor cells against apoptosis caused by TRAIL. Anticancer Drugs 21:10-24 (2010).Read more (PubMed: 19823077) »
See all 3 publications for this product
Publishing research using ab2019? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"