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DcR2 peptide (ab8379)

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Overview

Product name

DcR2 peptide

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

PBS with 0.1% BSA 0.02% sodium azide pH7.2

Concentration

Concentration information loading...

Sequence notes

GGPERVHRVL FRRRS Ami no acids 249 to 263 of human DcR2 (1-3)

Research areas

Cancer >> Invasion/microenvironment >> Apoptosis >> Death receptors & ligands >> TRAIL
Immunology >> Innate Immunity >> Cytokines >> Necrosis Factors
Cell Biology >> Apoptosis >> Receptors >> Decoy Receptors

Applications

Show applications key

Our Abpromise guarantee covers the use of ab8379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Blocking

     

Application notes

The peptide is used for blocking the activity of ab2019. Incubatingthe peptide with equal volume of antibody for 30 min at 37°C usually completely blocks theantibody activity in Western blotting.

Protein info

Function

Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway.

Tissue specificity

Widely expressed, in particular in fetal kidney, lung and liver, and in adult testis and liver. Also expressed in peripheral blood leukocytes, colon and small intestine, ovary, prostate, thymus, spleen, pancreas, kidney, lung, placenta and heart.

Sequence similarities

Contains 1 death domain.
Contains 3 TNFR-Cys repeats.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ9UBN6 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

References for DcR2 peptide (ab8379)

ab8379 has not yet been referenced specifically in any publications.

Publishing research using ab8379? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"