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Overview

  • Product nameDcp1a peptide (571-581)See all Dcp1a proteins and peptides ...
  • Protein descriptionSynthetic peptide: C-QVLTKNKDNHN, corresponding to C terminal amino acids 571-581 of Human Dcp1a. This peptide was used as an immunogen for ab47998 - Dcp1a antibody.

    • Properties

  • FormLyophilised:Please reconstitute this product in 100ul sterile water.
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Concentration information loading...
  • SequenceC-QVLTKNKDNHN
  • Research Areas

    • Protein info

    • Alternative names
        DCP1 decapping enzyme homolog ADcp1aDCP1A_HUMAN
        mRNA decapping enzyme 1AmRNA-decapping enzyme 1ASmad4 interacting transcriptional co activatorSmad4-interacting transcriptional co-activatorSmad4-interacting transcriptional co-activatorSMAD4IP1SMIFTranscription factor SMIF
      see all
  • FunctionNecessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
  • Tissue specificityDetected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
  • Sequence similaritiesBelongs to the DCP1 family.
  • Cellular localizationCytoplasm > P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.

    • Target information above from: UniProt accession Q9NPI6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Dcp1a peptide (571-581) (ab48045)

    ab48045 has not yet been referenced specifically in any publications.

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