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Overview

  • Product nameDcp1a peptideSee all Dcp1a proteins and peptides ...
  • Protein descriptionSynthetic peptide derived from within residues 300 - 400 of Human Dcp1a.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab47811 - Dcp1a antibody.
  • Protein length582 amino acids

    • Properties

  • Purity70 - 90% by HPLC
  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferInformation available upon request.
  • Concentration information loading...
  • Research Areas

    • Applications

  • Application notesThis peptide can be used with studies using ab47811.

    • Protein info

    • Alternative names
        DCP1 decapping enzyme homolog ADcp1aDCP1A_HUMAN
        mRNA decapping enzyme 1AmRNA-decapping enzyme 1ASmad4 interacting transcriptional co activatorSmad4-interacting transcriptional co-activatorSmad4-interacting transcriptional co-activatorSMAD4IP1SMIFTranscription factor SMIF
      see all
  • FunctionNecessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Contributes to the transactivation of target genes after stimulation by TGFB1.
  • Tissue specificityDetected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
  • Sequence similaritiesBelongs to the DCP1 family.
  • Cellular localizationCytoplasm > P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.

    • Target information above from: UniProt accession Q9NPI6 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    References for Dcp1a peptide (ab71605)

    ab71605 has not yet been referenced specifically in any publications.

    Publishing research using ab71605 ? Please let us know so that we can cite the reference in this datasheet

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