Dcp2 peptide (ab30458)

Product Name 

Dcp2 peptide

Product type 

Proteins and Peptides

Peptide 

Synthetic peptide derived from within residues 300 - 400 of Human Dcp2.


This peptide was used as an immunogen for ab28658 - Dcp2 antibody.

Research areas 

Chromatin and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding

Relevance 

Dcp2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Dcp2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a polyA tail. Has no activity towards a cap structure lacking a RNA moiety. Manganese is a cofactor that is required for highest activity.
Dcp2 is found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, RENT1, RENT2 and RENT3B. Interacts with DCP1A, DPC1B, RENT1, RENT2 and RENT3B. The complex associates with polysomes.

Storage buffer 

Preservative: None
Constituents: 0.001% Tween 20, 30mM HEPES, 2mM EDTA, 150mM Sodium chloride. pH 6.75

Form 

Liquid

Concentration 

1.000 mg/ml

Storage instructions 

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

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