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Overview
Product name
Dcp2 peptide
Protein description
Synthetic peptide derived from within residues 300 - 400 of Human Dcp2. (Note: the amino acid sequence is proprietary) This peptide was used as an immunogen for ab28658 - Dcp2 antibody.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
Information available upon request.
Concentration
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Research areas
Epigenetics and Nuclear Signaling >> Chromatin Binding Proteins >> DNA / RNA binding
Applications
Protein info
Relevance
Dcp2 is necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Dcp2 removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. It has higher activity towards mRNAs that lack a polyA tail. Has no activity towards a cap structure lacking a RNA moiety. Manganese is a cofactor that is required for highest activity. Dcp2 is found in a mRNA decay complex with LSM1, LSM3, LSM4, EXOSC2, EXOSC4, EXOSC10, PARN, XRN1, CNOT6, RENT1, RENT2 and RENT3B. Interacts with DCP1A, DPC1B, RENT1, RENT2 and RENT3B. The complex associates with polysomes.
Cellular localization
Cytoplasmic and Nuclear
References for Dcp2 peptide (ab30458)
ab30458 has not yet been referenced specifically in any publications.
Publishing research using ab30458? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"