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Anti-DeltaC antibody [zdc2] (ab73336)

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Overview

Product name

Anti-DeltaC antibody [zdc2]

Description

Mouse monoclonal [zdc2] to DeltaC

Specificity

Delta proteins activate Notch through a binding reaction that depends on their extracellular domains. During somitogenesis, Notch signalling via DeltaC keeps the oscillations of neighbouring cells in synchrony. DeltaC is also expressed in subsets of cells in the nervous system and elsewhere.

Tested applications

ELISA, WB, IHC-Fr, Flow Cyt, IHC - Wholemount, ICC/IFmore details

Cross reactivity

Reacts with

Zebrafish

Immunogen

Extracellular region of DeltaC protein (Zebrafish).

Epitope

DeltaC extracellular domain.

Positive control

HEK293 cells transfected with DeltaC or zebrafish embryo cryosections (formulin fixed).

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

zdc2

Myeloma

Sp2/0-Ag14

Isotype

IgG2a

Research areas

Developmental Biology >> Lineage specification >> Mesoderm
Developmental Biology >> Embryogenesis >> Somatogenesis
Stem Cells >> Signaling Pathways >> Notch >> Surface Molecules

Applications

Show applications key

Our Abpromise guarantee covers the use of ab73336 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

DeltaC acts as a ligand for Notch receptors and is involved in somitogenesis. It can activate Notch receptors. It is required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.

Cellular localization

Membrane; Single-pass type I membrane protein

Alternative names

  • Bea antibody
  • Beamter antibody
  • DelC antibody
  • Dlc antibody

Database links

References for Anti-DeltaC antibody [zdc2] (ab73336)

This product has been referenced in:

  • Giudicelli F  et al. Setting the tempo in development: an investigation of the zebrafish somite clock mechanism. PLoS Biol 5:e150 (2007).Read more (PubMed: 17535112) »

See 1 publication for this product

Publishing research using ab73336? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"