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Anti-DeltaD antibody [Dld 5C7/2, zdd2] (ab73331)

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Overview

Product name

Anti-DeltaD antibody [Dld 5C7/2, zdd2]

Description

Mouse monoclonal [Dld 5C7/2, zdd2] to DeltaD

Specificity

This antibody recognises the extracellular domain of zebrafish DeltaD. This antibody does not detect DeltaC; but it cross-reacts weakly with DeltaA.

Tested applications

ELISA, WB, IHC-Fr, Flow Cyt, ICC/IF, IHC - Wholemountmore details

Cross reactivity

Reacts with

Zebrafish

Immunogen

Extracellular DeltaD peptide (Zebrafish).

Epitope

Zebrafish DeltaD protein extracellular domain.

Positive control

HEK293 cells transfected with deltaD or zebrafish embryo.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Clone number

Dld 5C7/2, zdd2

Myeloma

Sp2/0-Ag14

Isotype

IgG1

Research areas

Developmental Biology >> Organogenesis >> Nervous system development
Developmental Biology >> Lineage specification >> Mesoderm
Developmental Biology >> Embryogenesis >> Somatogenesis
Neuroscience >> Neurology process >> Neurogenesis
Cell Biology >> Cell Cycle >> Cell differentiation
Neuroscience >> Neurology process >> Notch Pathway

Applications

Show applications key

Our Abpromise guarantee covers the use of ab73331 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Target

Relevance

DeltaD is one of the 4 members of the zebrafish Delta family of Notch ligands, important in the control of cell differentiation in many tissues. DeltaD acts as a ligand for Notch receptors and is involved in primary neurogenesis and somitogenesis. It can activate Notch receptors, thereby playing a key role in lateral inhibition, a process that prevents the immediate neighbors of each nascent neural cell from simultaneously embarking on neural differentiation. It is required in somite segmentation to keep the oscillations of neighboring presomitic mesoderm cells synchronized.

Cellular localization

Cell Membrane

Alternative names

  • Aei antibody
  • After eight antibody
  • dld antibody

Database links

References for Anti-DeltaD antibody [Dld 5C7/2, zdd2] (ab73331)

This product has been referenced in:

  • Hong SK & Dawid IB The transcriptional mediator component med12 is required for hindbrain boundary formation. PLoS One 6:e19076 (2011). ICC/IF; Zebrafish.Read more (PubMed: 21533047) »
  • Fujita M  et al. Assembly and patterning of the vascular network of the vertebrate hindbrain. Development 138:1705-15 (2011).Read more (PubMed: 21429985) »

See all 5 publications for this product

Publishing research using ab73331? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"