Desmin antibody (ab6570)

Product Name 

Desmin antibody

Product type 

Primary antibodies

Description 

Rabbit polyclonal to Desmin

Immunogen 

Full length native protein (purified) (Chicken).

Reacts with 
(species key)

Hu, Ms, Chk, Cow

Specificity 

The antibody specifically stains the wide desmin band of 50,000 to 55,000 molecular weight in immunoblotting.

Tested applications 
(see key)

ICC/IF

Abreviews 

Customer reviews (see key)

Read about Abreviews

Application notes 
(see key)

Recommended dilutions
IF: 1/20.

Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.

Cellular localization 

Cytoplasmic

Research areas 

Cancer >> Invasion/microenvironment >> ECM >> Extracellular matrix >> Other
Stem Cells >> Mesenchymal Stem Cells >> Myogenesis
Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Intermediate Filaments >> Class III >> Desmin

Relevance 

Desmins belongs to the intermediate filament family, and are class III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z line structures. Defects in Desmin are the cause of desmin related cardio skeletal myopathy (CSM) also known as desmin related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin reactive deposits in cardiac and skeletal muscle cells. A desmin related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM). Defects in Desmin are also the cause of dilated cardiomyopathy type 1I (CMD1I). CMD1I is an autosomal form of dilated cardiomyopathy characterized by ventricular dilatation and impaired systolic function. Antidesmin antibodies are useful in identification of tumours of myogenic origin.

Rabbit Anti-Desmin may be used for immunocyto-chemical localization of intermediate filaments of the desmin group in all types of muscle cells and to localize desmin at the periphery of z-discs. The product also specifically stains desmin when used in immunoblotting.

Database links 

Raised in 

Rabbit

Clonality 

Polyclonal

Isotype 

IgG

Purity 

Whole antiserum

Storage buffer 

serum with 0.1% sodium azide

Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS

Purification notes 

The antiserum has been treated to remove lipo-proteins.

Form 

Liquid

Concentration 

63.000 mg/ml

Storage instructions 

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Notes 

Desmin is the protein subunit of muscle-type intermediate filaments (IFs). IFs, with characteristic 10 nm diameter are a distinct class of heterogenous protein subunits apparent by both immunological and biochemical criteria. IFs differ significantly from the other cytoskeletal elements of the cell, namely microtubules & microfilaments, and are components of most eukaryotic cells. Desmin is one of the five major groups of IFs and is found in predominatly in skeletal, cardiac and smooth muscle.

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