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SDS-PAGE - Diazepam Binding Inhibitor protein (Tagged) (ab84342)
(enlarge)
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Product Name
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Diazepam Binding Inhibitor protein (Tagged)
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Product type
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Proteins and Peptides
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Peptide
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Recombinant full length human Diazepam Binding Inhibitor with proprietary tag; amino acids 1-87, 38kDa. Swiss ID = P07108
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Tested applications
(see key)
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SDS-PAGE
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Application notes
(see key)
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Recommended dilutions
SDS-PAGE: Use at an assay dependent dilution.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Research areas
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Neuroscience >> Neuropharmacology >> Molecular Neuropharmacology
Neuroscience >> Neurology process >> Neurodegenerative disease >> Alzheimer's disease >> Other
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Relevance
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Diazepam Binding Inhibitor(DBI) is a highly conserved 10kDa polypeptide which is expressed in various species range from yeast to mammals. As an inverse agonist for benzodiazepine receptors, DBI downregulates inhibitory effects of GABA. It also has potential to induce anxiety. Found in central and peripheral tissues, DBI also participates in metabolism of steroids, which has been known to partially modify GABAA receptor function in the CNS. In peripheral tissues, DBI plays regulatory roles in steroidogenesis. DBI levels have been reported to be decreased in the cerebrospinal fluid obtained from patients with Alzheimer disease.
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Diazepam Binding Inhibitor protein (Tagged) (ab84342) |
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Purity
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Purified via GST Tag
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Storage buffer
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Preservative: None
Constituents: 10% Glycerol, 20mM HEPES, pH 7.0 Material safety datasheet (MSDS) for this product:
Glycerol MSDS
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Purification notes
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Purified
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Form
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Lyophilised
Reconstitute in 20mM HEPES, pH 7.0
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Concentration
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1.000 mg/ml
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Storage instructions
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Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
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Notes
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ab84342 is supplied with a vial of storage buffer (20mM HEPES, pH7.0/10%
Glycerol).
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Expression system
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E. coli
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this Diazepam Binding Inhibitor protein (Tagged) is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for Diazepam Binding Inhibitor protein (Tagged) images, references, products related to ab84342 and other tools.
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Diazepam Binding Inhibitor protein (Tagged) images:
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 SDS-PAGE - Diazepam Binding Inhibitor protein (Tagged) (ab84342)
SDS-PAGE showing ab84342 at approximately 38kDa (1µg).
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Search PubMed (MEDLINE) for references to Diazepam Binding Inhibitor
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Diazepam Binding Inhibitor protein (Tagged) - more information
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Diazepam Binding Inhibitor protein (Tagged) - other tools:
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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