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Product name
Diclofenac Sodium
Description
Potent cyclo-oxygenase inhibitor
Biological description
Potent non-selective COX inhibitor (IC50 values are 75 and 29 nM at COX-1 and COX-2 respectively). Potent inhibitor of phospholipase A2 in vitro and in vivo. Activates the nitric oxide-cyclic GMP-potassium channel pathway. Shows anti-inflammatory, anti-pyretic and analgesic effects.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
Molecular Weight
318.13
Chemical structure
Molecular formula
C14H10Cl2NNaO2
CAS Number
15307-79-6
Solubility
Soluble in water to 50 mM (at room temperature) and in water to 100 mM (with warming)
Storage instructions
Store at room temperature (desiccating conditions).
Research areas
Biochemicals >> Research Area >> Stroke >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Respiratory disease >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Pain & inflammation >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Obesity >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Hypertension >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Heart disease >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Diabetes >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Cancer >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Research Area >> Alzheimer's Disease >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Pharmacology >> Signaling >> Lipid signaling >> Cyclooxygenase >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Cytochrome P450 >> Inhibitors
Biochemicals >> Pharmacology >> Enzymes >> Cyclooxygenase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Diclofenac Sodium (ab120621)
This product has been referenced in:
- León-Reyes MR et al. Pharmacokinetics and pharmacodynamics of diclofenac in the presence and absence of glibenclamide in the rat. J Pharm Pharm Sci 11:68-76 (2008).Read more (PubMed: 18801308) »
- Warner TD et al. Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci U S A 96:7563-8 (1999).Read more (PubMed: 10377455) »
See all 4 publications for this product
Publishing research using ab120621? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"