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Overview

  • Product nameDihydrokainic acid
  • Description
    EAAT2 inhibitor
  • Alternative names
    DHK
  • Biological descriptionSelective, non-transportable inhibitor of glutamate transporter EAAT2 (Ki = 23 μM). 130-fold selective over EAAT1 and EAAT3 (Ki > 3 mM).
  • Purity> 99%

    • Properties

  • Chemical name(2S,3S,4R)-3-(Carboxymethyl)-4-isopropylpyrrolidine-2-carboxylic acid
  • Molecular Weight215.25
  • Chemical structureChemical Structure
  • Molecular formulaC10H17NO4
  • CAS Number52497-36-6
  • PubChem identifier107883
  • Storage instructionsStore at +4°C (desiccating conditions).
  • Solubility overviewSoluble in water to 25 mM
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

  • SMILESCC(C)[C@H]1CN[C@@H]([C@H]1CC(=O)O)C(=O)O
  • Source

    Synthetic

  • Research Areas

    • References for Dihydrokainic acid (ab120066)

    This product has been referenced in:
    • Fallgren AB & Paulsen RE A microdialysis study in rat brain of dihydrokainate, a glutamate uptake inhibitor. Neurochem Res 21:19-25 (1996). Read more (PubMed: 8833219) »
    • Arriza JL  et al. Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J Neurosci 14:5559-69 (1994). Read more (PubMed: 7521911) »
    • Muñoz MD  et al. Effects of dihydrokainic acid on extracellular amino acids and neuronal excitability in the in vivo rat hippocampus. Neuropharmacology 26:1-8 (1987). Read more (PubMed: 2882438) »

    See all 2 Publications for this product

    Publishing research using ab120066 ? Please let us know so that we can cite the reference in this datasheet

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"