Overview

  • Product nameAnti-Dio3 antibody
    See all Dio3 primary antibodies
  • Description
    Rabbit polyclonal to Dio3
  • Tested applicationsWBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal residues 250-300 of Rat Dio3.

  • Positive control
    • Rat placenta lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab82041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 µg/ml. Detects a band of approximately 31 kDa (predicted molecular weight: 31 kDa).

Target

  • FunctionResponsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
  • Tissue specificityExpressed in placenta and several fetal tissues.
  • Sequence similaritiesBelongs to the iodothyronine deiodinase family.
  • Cellular localizationCell membrane. Endosome membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • 5DIII antibody
    • D3 antibody
    • Deiodinase iodothyronine type 3 antibody
    • Deiodinase iodothyronine type III antibody
    • Dio 3 antibody
    • Dio3 antibody
    • DIOIII antibody
    • IOD3_HUMAN antibody
    • Iodothyronine deiodinase placental type antibody
    • MGC124117 antibody
    • MGC124118 antibody
    • Thyroxine deiodinase type III antibody
    • Thyroxine deiodinase type III (selenoprotein) antibody
    • TXDI3 antibody
    • Type 3 DI antibody
    • Type 3 iodothyronine selenodeiodinase antibody
    • Type III 5' deiodinase antibody
    • Type III iodothyronine deiodinase antibody
    • Type-III 5''-deiodinase antibody
    see all

Anti-Dio3 antibody images

  • Anti-Dio3 antibody (ab82041) at 0.5 µg/ml + rat placenta lysate

    Predicted band size : 31 kDa
    Observed band size : 31 kDa

References for Anti-Dio3 antibody (ab82041)

This product has been referenced in:
  • Bedolla DE & Torre V A component of retinal light adaptation mediated by the thyroid hormone cascade. PLoS One 6:e26334 (2011). WB ; Rat . Read more (PubMed: 22039463) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"