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Overview

  • Product nameAnti-Dio3 antibodySee all Dio3 primary antibodies ...
  • Description
    Rabbit polyclonal to Dio3
  • Tested applicationsWB more details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide corresponding to a region within internal residues 250-300 of Rat Dio3.

  • Positive controlRat placenta lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab82041 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Notes
WB WB: Use a concentration of 0.5 µg/ml. Detects a band of approximately 31 kDa (predicted molecular weight: 31 kDa).

Target

  • FunctionResponsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into RT3 (3,3',5'-triiodothyronine) and of T3 (3,5,3'-triiodothyronine) into T2 (3,3'-diiodothyronine). RT3 and T2 are inactive metabolites. May play a role in preventing premature exposure of developing fetal tissues to adult levels of thyroid hormones. Can regulate circulating fetal thyroid hormone concentrations throughout gestation. Essential role for regulation of thyroid hormone inactivation during embryological development.
  • Tissue specificityExpressed in placenta and several fetal tissues.
  • Sequence similaritiesBelongs to the iodothyronine deiodinase family.
  • Cellular localizationCell membrane. Endosome membrane.

    • Target information above from: UniProt accession P55073 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links
    see all
  • Alternative names
      5DIII antibodyD3 antibodyDeiodinase iodothyronine type 3 antibody
      Deiodinase iodothyronine type III antibodyDio 3 antibodyDio3 antibodyDIOIII antibodyIOD3_HUMAN antibodyIodothyronine deiodinase placental type antibodyMGC124117 antibodyMGC124118 antibodyThyroxine deiodinase type III antibodyThyroxine deiodinase type III (selenoprotein) antibodyTXDI3 antibodyType 3 DI antibodyType 3 iodothyronine selenodeiodinase antibodyType III 5' deiodinase antibodyType III iodothyronine deiodinase antibodyType-III 5''-deiodinase antibody
    see all

Anti-Dio3 antibody images

  • Western blot - Dio3 antibody (ab82041)
    Western blot - Dio3 antibody (ab82041)
    Anti-Dio3 antibody (ab82041) at 0.5 µg/ml + rat placenta lysate

    Predicted band size : 31 kDa
    Observed band size : 31 kDa

References for Anti-Dio3 antibody (ab82041)

This product has been referenced in:
  • Bedolla DE & Torre V A component of retinal light adaptation mediated by the thyroid hormone cascade. PLoS One 6:e26334 (2011). WB ; Rat . Read more (PubMed: 22039463) »

See 1 Publication for this product

Publishing research using ab82041 ? Please let us know so that we can cite the reference in this datasheet

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