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Product name
Dipyridamole
Description
Non selective phosphodiesterase (PDE) inhibitor
Biological description
Non selective phosphodiesterase (PDE) inhibitor. Exerts anti -platelet, anti-inflammatory, anti-oxidative and anti-fibrotic effects. Inhibits hydrolysis of cyclic AMP (cAMP) and cGMP (IC50 = 5µM and 3 µM respectively) in vitro.
Purity
> 99%
General notes
Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Properties
Chemical name
2,6-Bis(diethanolamino)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Molecular Weight
504.63
Chemical structure
Molecular formula
C24H40N8O4
CAS Number
58-32-2
Solubility
Soluble in DMSO to 100 mM and in ethanol to 10 mM
Storage instructions
Store at room temperature.
Research areas
Biochemicals >> Pharmacology >> Enzymes >> Phosphodiesterase >> Inhibitors
Biochemicals >> Chemical Type >> Biochemicals
References for Dipyridamole (ab120451)
This product has been referenced in:
- Hsieh MS et al. Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells. Circ J 74:1242-50 (2010).Read more (PubMed: 20453393) »
- Kim HH & Liao JK Translational therapeutics of dipyridamole. Arterioscler Thromb Vasc Biol 28:s39-42 (2008).Read more (PubMed: 18174451) »
See all 3 publications for this product
Publishing research using ab120451? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"