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Overview

  • Product nameDopamine D2 Receptor proteinSee all Dopamine D2 Receptor proteins and peptides ...
  • Protein descriptionRecombinant fragment (aa 1-110) of Human Dopamine D2 Receptor with proprietary tag (M.Wt 37.73kDa) UniProt P14416.
  • Uniprot accessionP14416
  • Molecular weight37.730kDa inclusive of tags
  • Protein length110 amino acids
  • Expression hostWheat germ

    • Properties

  • Biological activityuseful for Antibody Production and Protein Array
  • FormLiquid
  • Storage instructionsShipped on dry ice. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage bufferpH: 8.00
    Constituents: 0.79% Tris HCl, 0.31% Glutathione
    Note: Reduced glutathione
  • Concentration information loading...
  • Additional notesBest use within three months from the date of receipt of this protein.
  • SequenceMDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATL LTLLIAVIVF GNVLVCMAVSREKALQTTTNYLIVSLAV ADLLVATLVMPWVVYLEVVGEW KFSRIHCDIF
  • Research Areas

    • Applications

    Our Abpromise guarantee covers the use of ab112281 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Notes
    WB WB: Use at an assay dependent concentration. Predicted molecular weight: 37.73 kDa. This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.
    SDS-PAGE SDS-PAGE: Use at an assay dependent concentration.
    ELISA ELISA: Use at an assay dependent concentration.
    PepArr PepArr: Use at an assay dependent concentration.

    Protein info

    • Alternative names
        D(2) dopamine receptorD2 dopamine receptorD2DR
        D2RDopamine D2 receptorDopamine receptor D2DRD 2DRD2DRD2_HUMAN
      see all
  • FunctionThis is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.
  • Involvement in diseaseDefects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable.
  • Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
  • Cellular localizationCell membrane.

    • Target information above from: UniProt accession P14416 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

    Dopamine D2 Receptor protein images

    • SDS-PAGE - Dopamine D2 Receptor protein (ab112281)
      SDS-PAGE - Dopamine D2 Receptor protein (ab112281)
      12.5% SDS-PAGE Stained with Coomassie Blue with recombinant protein.

    References for Dopamine D2 Receptor protein (ab112281)

    ab112281 has not yet been referenced specifically in any publications.

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