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Anti-Dopamine Transporter antibody (ab18548)

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Overview

Product name

Anti-Dopamine Transporter antibody
See all Dopamine Transporter products (6) ...

Description

Rabbit polyclonal to Dopamine Transporter

Tested applications

ELISA, WBmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Synthetic peptide (Human) conjugated to KLH (C terminal).

Properties

Form

Liquid

Storage instructions

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: 40% Glycerol

Purity

Whole antiserum

Clonality

Polyclonal

Isotype

IgG

Research areas

Neuroscience >> Neurotransmitter >> Transporters >> Dopamine
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine

Applications

Show applications key

Our Abpromise guarantee covers the use of ab18548 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ELISA

     ELISA: 1/100,000

    ELISA: 1/100,000

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    WB

      See more...Read more →

    WB: 1/1000 - 1/5000.Predicted molecular weight: 68 kDa.(

    An antibody raised against a similar peptide has been shown to react with a broad 80kD band in rat striatum and not cerebellum. The 80kD band comigrates with rat DAT labeled with an affinity ligand 125I-DEEP. The 80kD DAT band can be competed with the immunizing peptide. The same 80kD band (125I-DEEP labeled) can also be immunoprecipitated using the antiserum. Rat DAT contains various carbohydrate moieties and neuramnidase and N-Glycanase treatment reduces it size to ~55kD.)

Target

Function

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Involvement in disease

Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ01959 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DA transporter antibody
  • DAT 1 antibody
  • DAT 1 antibody
  • DAT antibody
  • DAT1 antibody
  • DAT1 antibody
  • Dopamine transporter antibody
  • SC6A3_HUMAN antibody
  • SLC6A3 antibody
  • SLC6A3 antibody
  • Sodium dependent dopamine transporter antibody
  • Sodium-dependent dopamine transporter antibody
  • Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody
  • Solute carrier family 6 member 3 antibody
  • Variable number tandem repeat (VNTR) antibody
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Database links

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References for Anti-Dopamine Transporter antibody (ab18548)

ab18548 has not yet been referenced specifically in any publications.

Publishing research using ab18548? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"