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Products:Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine
Overview
Product name
Anti-Dopamine Transporter antibody
See all Dopamine Transporter products (6) ...
Description
Rabbit polyclonal to Dopamine Transporter
Specificity
Ab27950 recognises Dopamine transporter.
Tested applications
WB, Dot Blot, IHC-FoFrmore details
Cross reactivity
Reacts with
Human, Monkey
Immunogen
Synthetic peptide from the EL2 region of human Dopamine Transporter.
Positive control
Human and monkey striatum and brain tissue.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage buffer
Preservative: None
Constituents: 50% Glycerol, 0.1mg/ml BSA, 150mM Sodium chloride, 10mM HEPES. pH 7.5.
Concentration
Concentration information loading...
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Research areas
Neuroscience >> Neurotransmitter >> Transporters >> Dopamine
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine
Applications
Show applications key
Our Abpromise guarantee covers the use of ab27950 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
WB
Dot Blot
IHC-FoFr
Application notes
Dot: 1/1000.
IHC-F: 1/1000.
WB: 1/1000. Predicted molecular weight: 68 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Function
Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Involvement in disease
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.
Sequence similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.
Cellular localization
Membrane.
Target information above from: UniProt accessionQ01959
The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).
Alternative names
- DA transporter antibody
- DAT 1 antibody
- DAT antibody
see all
Database links
- Entrez Gene: 6531 Human
- Omim: 126455 Human
- SwissProt: Q01959 Human
- Unigene: 406 Human
References for Anti-Dopamine Transporter antibody (ab27950)
This product has been referenced in:
- Boyer F & Dreyer JL The role of gamma-synuclein in cocaine-induced behaviour in rats. Eur J Neurosci 27:2938-51 (2008). WB.Read more (PubMed: 18588534) »
See 1 publication for this product
Publishing research using ab27950? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"