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Anti-Dopamine Transporter antibody (ab5990)

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Overview

Product name

Anti-Dopamine Transporter antibody
See all Dopamine Transporter products (6) ...

Description

Rat monoclonal to Dopamine Transporter

Specificity

This antibody recognizes the N-terminus of the dopamine transporter (DAT-NT) in rats and humans.

Tested applications

WB, ICC, IHC-Frmore details

Cross reactivity

Reacts with

Mouse, Rat, Human

Immunogen

Fusion protein containing the dopamine transporter N-terminal amino acids 1-66.

Properties

Form

Liquid

Storage instructions

Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Storage buffer

Preservative: None
Constituents: PBS
Sterile Filtered

Concentration

Concentration information loading...

Purity

Protein A purified

Clonality

Monoclonal

Isotype

IgG

Research areas

Neuroscience >> Neurotransmitter >> Transporters >> Dopamine
Neuroscience >> Neurotransmitter >> Biogenic Amines >> Dopamine

Applications

Show applications key

Our Abpromise guarantee covers the use of ab5990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • ShowHide

    WB

     WB: 1/500Predicted molec...Read more →

    WB: 1/500Predicted molecular weight: 74 kDa.

  • ICC

     ICC: 1/100 - 1/1000.

    ICC: 1/100 - 1/1000.

  • IHC-Fr

     IHC-Fr: 1/500

    IHC-Fr: 1/500

Target

Function

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Involvement in disease

Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile (DYTPRI) [MIM:613135]. It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.

Cellular localization

Membrane.

Target information above from: UniProt accessionQ01959 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010).

Information by UniProt

Alternative names

  • DA transporter antibody
  • DAT 1 antibody
  • DAT antibody
  • DAT1 antibody
  • Dopamine transporter antibody
  • SC6A3_HUMAN antibody
  • SLC6A3 antibody
  • Sodium dependent dopamine transporter antibody
  • Sodium-dependent dopamine transporter antibody
  • Solute carrier family 6 (neurotransmitter transporter dopamine), member 3 antibody
  • Solute carrier family 6 member 3 antibody
  • Variable number tandem repeat (VNTR) antibody
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Database links

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References for Anti-Dopamine Transporter antibody (ab5990)

This product has been referenced in:

  • Garfield ASet al. Distinct physiological and behavioural functions for parental alleles of imprinted Grb10. Nature 469:534-8 (2011). IHC (PFA fixed); Mouse.Read more (PubMed: 21270893) »
  • Friling Set al. Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells. Proc Natl Acad Sci U S A 106:7613-8 (2009). IHC; Mouse.Read more (PubMed: 19383789) »

See all 3 publications for this product

Publishing research using ab5990? Please let us know so that we can cite the reference in this datasheet

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"