Overview
Product nameDscam peptideSee all Dscam proteins and peptides ...
Protein descriptionSynthetic peptide derived from within residues 1150 - 1250 of Human Dscam.(Note: the amino acid sequence is proprietary)This peptide was used as an immunogen for ab43847 - Dscam antibody.
Protein length2016 amino acids
Properties
Purity70 - 90% by HPLC
FormLiquid
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage bufferInformation available upon request.
Concentration information loading...
Research Areas
Applications
Application notesThis peptide can be used with studies using ab43847.
Protein info
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Alternative names
Down syndrome cell adhesion moleculeDSCAMDSCAM_HUMANhuman CHD2-52 down syndrome cell adhesion molecule 2, 9OTTHUMP00000109193 2SD11109p
see all
FunctionCell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord development plays a role in guiding commissural axons projection and pathfinding across the ventral midline to reach the floor plate upon ligand binding. Enhances netrin-induced phosphorylation of PAK1 and FYN. Mediates intracellular signaling by stimulating the activation of MAPK8 and MAP kinase p38.
Tissue specificityPrimarily expressed in brain.
Sequence similaritiesContains 6 fibronectin type-III domains.
Contains 10 Ig-like C2-type (immunoglobulin-like) domains.
DomainIg-like C2-type domains 7 to 9 are sufficient for interaction with NTN1 and commissural axon outgrowth. The transmembrane domain is necessary for interaction with DCC.
Post-translational
modificationsPhosphorylated at tyrosine residues. Phosphorylation is enhanced by netrin.
Cellular localizationSecreted and Cell membrane. Localized in the soma, cell membrane, axon and growth cone of dissociated commissural axons.
References for Dscam peptide (ab43846)
ab43846
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
